Abokan ciniki na Makarantar Kimiyyar Rayuwa, Jami'ar Sichuan ta buga takardu masu girma ta amfani da samfuran Foregene, tare da tasirin tasirin 17.848

Kwanan nan, tawagar Song Xu daga Makarantar Kimiyyar Rayuwa ta Jami'ar Sichuan ta buga takarda mai takenAbubuwan coagulation VII, IX da X sune sunadaran ƙwayoyin cuta na ƙwayoyin cuta na ƙwayoyin cuta na Gram-korau a cikin Binciken Tantanin halitta.

Binciken Cell, jarida ce ta kasa da kasa tare da Cibiyar Nazarin Kimiyya ta kasar Sin da kungiyar wallafe-wallafen dabi'ar Biritaniya, wacce ke da iko sosai a duniyar ilimi.

Da zarar an buga wannan labarin, nan da nan ya haifar da jin daɗi a cikin ilimin kimiyya.Ya zuwa yanzu, sakamakon binciken ya samu karbuwa daga kafofin yada labarai da dama kamar kamfanin dillancin labarai na Xinhua, gidan yanar gizo na duniya, Phoenix Net, Southern Metropolis Daily,Kwarin Halittu, Wasiƙar Daily ta Burtaniya, Kimiyyar Zamani ta Amurka, EurekAlert1!, Yanayin Springer, Phys.org, da sauransu., BioMedCentral da sauran sanannun mujallu suna da rahotanni masu yawa, kuma hankalin duniya ga wannan sakamakon bincike yana ci gaba da girma.

Labarin ya nuna cewa abubuwa guda uku na coagulation VII, IX da X da ke taka rawa wajen farawar coagulation cascade wani sabon nau'i ne na furotin na ƙwayoyin cuta na ƙwayoyin cuta, wato, abubuwan coagulation VII, IX da X suna da muhimmiyar rawa a cikin tsarin coagulation.Hakanan yana iya yin yaƙi da ƙwayoyin cuta na Gram, gami da “super bacteria” masu juriya sosai kamar Pseudomonas aeruginosa da Acinetobacter baumannii.

Song Xu, mawallafin wannan labarin, ya ce: "A da, an yi imani da cewa abubuwan da ke haifar da coagulation na iya haifar da thrombosis, amma wannan binciken ya nuna cewa abubuwan da ke haifar da coagulation suna da tasiri na musamman na haifuwa.Wannan shine karo na farko da aka gano a gida da waje.”

Bayanan Bincike

Kamar yadda muka sani, juriya na ƙwayoyin cuta ya zama mummunar matsalar lafiyar jama'a a duniya.Bayanan da suka dace sun nuna cewa kusan mutane miliyan 1 ne ke mutuwa daga cututtukan ƙwayoyin cuta masu jure wa ƙwayoyi a duk shekara.Idan ba a sami mafita mafi kyau ba, adadin mace-mace a kowace shekara daga 2050 zai zama miliyan 10.

Cin zarafi na maganin rigakafi, tare da kyakkyawan ƙarfin juyin halitta na ƙwayoyin cuta, ya sa wasu ƙwayoyin cuta masu cutarwa waɗanda magungunan kashe kwayoyin cuta zasu iya kashe su zama masu jure wa miyagun ƙwayoyi, sun zama kusan "super bacteria".

Bugu da ƙari, idan aka kwatanta da kwayoyin cutar Gram-positive (Gram +), ƙwayoyin cuta marasa kyau (Gram-) sun fi wuya a kashe saboda kasancewar membrane na waje (babban sashi shine LPS, alias endotoxin, lipopolysaccharide).Ambulan waje wani ambulan ne wanda ya ƙunshi membrane na sel na ciki, bangon tantanin halitta na bakin ciki da membrane na waje.

Tarihin bincike

Tawagar Song Xu ta dade tana nazarin tasirin abubuwan da ke haifar da coagulation na maganin ciwace-ciwacen daji, amma a shekarar 2009, ba zato ba tsammani, an gano cewa abubuwan da ke haifar da coagulation na iya kashe kwayoyin cuta.Don yin bayanin tsarin ƙwayoyin cuta na abubuwan haɗin gwiwa, aikin ya kasance shekaru 10 daga farkon binciken har zuwa buga takarda.

An samu kwatsam

A cikin 2009, masu bincike sun gano da gangan cewa coagulation factor VII na iya yaƙi da Escherichia coli a cikin fiye da dozin abubuwan coagulation.

Escherichia coli na cikin kwayoyin cutar Gram-negative a cikin kwayoyin cuta.Irin wannan nau'in kwayoyin cuta yana da wuyar magancewa, saboda ƙwayoyin su suna da membrane na ciki, bangon tantanin halitta da kuma membrane na waje.Ambulaf ɗin zai iya ajiye magungunan kuma ya kare ƙwayoyin cuta daga "kutsawa."

Ba da shawarar zato

Abubuwan da ke haifar da coagulation rukuni ne na sunadaran da ke cikin jini waɗanda ke da hannu wajen toshewar jini.Lokacin da raunin jikin ɗan adam ya haifar da zubar jini, ana kunna abubuwan coagulation daban-daban mataki-mataki don samar da fibrin filaments, wanda ke rufe raunin tare da platelets.Idan daya ko da yawa abubuwan coagulation sun rasa, rashin lafiyar coagulation zai faru.

Masana kimiyya sun lura cewa marasa lafiya tare da coagulopathy sau da yawa suna fuskantar cututtuka na kwayan cuta irin su sepsis da ciwon huhu.Wannan haɗin kai ya sa su yi hasashe cewa abubuwan haɗin gwiwa na iya ba kawai taka muhimmiyar rawa a cikin tsarin coagulation ba, amma kuma suna iya samun sakamako na rigakafin kamuwa da cuta.

Bincike mai zurfi

Don bincika ko abubuwan haɗin gwiwa zasu iya magance nau'ikan ƙwayoyin cuta na Gram-negative, masu bincike sun fara nazarin tsarin sa na ƙwayoyin cuta cikin zurfi.Sun gano cewa coagulation factor VII da tsarin kamanceceniya abubuwa IX da factor X, waɗannan sunadaran guda uku zasu iya karya ta cikin ƙwaƙƙarfan ambulan na ƙwayoyin cuta gram-korau.

Yawancin abubuwan da ake amfani da su na kashe kwayoyin cuta suna yin niyya ga metabolism na sel ko membranes tantanin halitta, amma waɗannan abubuwan haɗin gwiwa guda uku suna da nau'ikan ayyuka daban-daban.Za su iya hydrolyzes LPS, babban bangaren na kwayan cuta m membrane.Rasa LPS yana da wahala ga ƙwayoyin cuta Gram-korau su rayu.

Ci gaba

Tawagar binciken ta kara binciki tsarin kuma ta gano hakanfurotin na coagulation factor yana aiki akan kwayoyin cuta ta hanyar sashin sarkarsa mai haske, yayin da sashin sarkar mai nauyi ba shi da wani tasiri na kashe kwayoyin cuta.

A cikin yanayin al'adar dakin gwaje-gwaje, masu binciken sun lura a fili cewa bayan sun hada da sinadarin coagulation ko abubuwan da ke tattare da sarkar haskensa, ambulan kwayoyin cutar ya fara lalacewa, sannan a cikin sa'o'i 4, dukkanin kwayoyin cutar sun kusan lalata gaba daya.

Ƙara factor VII bangaren sarkar haske zuwa Escherichia coli mai al'ada,

Abubuwan da ke tattare da ƙwayoyin ƙwayoyin cuta na waje sun lalace, sel sun lalace

Ba wai kawai Escherichia coli ba, amma wasu kwayoyin cutar Gram-korau da aka gwada suma an “ci nasara”, gami da Pseudomonas aeruginosa da Acinetobacter baumannii.Dukkan wadannan kwayoyin cuta guda biyu hukumar lafiya ta duniya WHO ta bayyana su a matsayin kwayoyin cuta guda 12 da suka fi yin barazana ga lafiyar dan adam saboda juriyarsu.

Tabbatar da gwaji

Gwaje-gwajen dabbobi masu zuwa sun kara tabbatar da ingancin abubuwan da ke damun jini a kan superbacteria.

Masu binciken sun yi wa berayen allura da adadi mai yawa na Pseudomonas aeruginosa masu jure magunguna ko Acinetobacter baumannii.Bayan alluran sarkar haske mai yawa na factor VII, berayen sun tsira;yayin da berayen da ke cikin rukunin da aka yi wa allurar saline na yau da kullun sun kasance 24 Duk sun mutu sakamakon kamuwa da cuta bayan sa'o'i.

Bayan kamuwa da cuta tare da super bacteria, jiko na factor VII sarkar haske

Zai iya taka rawar kariya kuma yana inganta ƙimar rayuwar beraye sosai

Muhimmanci

A halin yanzu, babu wani abu na ƙwayoyin cuta da aka san yana da tasiri ta hanyar hydrolyzing LPS.

Bayyana tsarin aikin ƙwayoyin cuta wanda ya dogara da LPS hydrolysis da halayen ƙwayoyin cuta na abubuwan coagulation, hade tare da ikon samar da waɗannan abubuwan haɗin gwiwa a kan babban sikelin akan farashi mai rahusa, na iya samar da sabon dabarun da za a iya amfani da shi don yaƙar ƙwayoyin ƙwayoyin cuta na Gram-korau Cutar gaggawa ta haifar da matsalar lafiyar jama'a.

Bugu da ƙari, wannan aikin yana da fa'idodin aikace-aikacen aikace-aikacen a cikin aikin asibiti.A halin yanzu, babu sanannun magungunan ƙwayoyin cuta da ke yin tasiri ta hanyar hydrolyzing LPS.Haɗuwa da kaddarorin ƙwayoyin cuta na FVII, FIX, da FX akan LPS da ƙananan ƙima mai ƙima, ana tsammanin haɓaka sabbin ƙwayoyi akan cututtukan “super bacteria”.

Tsawaita batun

Ko da yake mutane sun fi sanin sunan “super bacteria”, ainihin kalmarsu ya kamata ya zama “bakteriya masu jure wa miyagun ƙwayoyi”, wanda ke nufin nau’in ƙwayoyin cuta masu jure wa maganin rigakafi da yawa.

Kamar yadda aka ambata a baya, haɓakar juriya na ƙwayoyin cuta a halin yanzu ya samo asali ne saboda rashin amfani da rashin amfani ko ma cin zarafin ƙwayoyin cuta.Misali, yawan amfani da maganin kashe kwayoyin cuta masu fadi a cikin maganin cututtukan da ke dauke da numfashi.

Cutar cututtukan da ke haifar da numfashi cuta ce da muka saba da ita.Bisa kididdigar da aka yi, kowane yaro yana kamuwa da cutar kusan sau 6 zuwa 9 a shekara, kuma matasa da manya suna kamuwa da cutar kusan sau 2 zuwa 4 a shekara.

Saboda cututtuka na numfashi sau da yawa sassan gaggawa ne, babban matsala ga likitocin gaggawa a lokacin da suke fuskantar marasa lafiya shi ne ba za su iya samun bayanan cututtuka a cikin gajeren lokaci ba.Sabili da haka, rashin jinkirin gwaje-gwajen cututtuka yana sa likitoci suyi amfani da maganin rigakafi masu yawa (wanda zai iya zama tasiri).Ga nau'ikan kwayoyin cuta).

Wannan hanyar "yaɗa babbar hanyar yanar gizo" ce ta hanyar magani wanda ya haifar da ƙara matsananciyar matsalar juriyar ƙwayoyin cuta.Domin lokacin da akasarin nau'in m da ci gaba ana ci gaba da kashe shi, ƙwayoyin cuta masu tsayayya da magani don maye gurbin miyagun ƙwayoyin cuta, da kuma ƙwarewar ƙwayoyin cuta na ƙwayoyin cuta za su ci gaba da ƙaruwa.

Don haka, idan za a iya samun cikakken rahoton gano ƙwayoyin cuta a cikin ɗan gajeren lokaci don jagorantar likitocin wajen rubuta magungunan da suka dace, za a iya rage yawan amfani da maganin rigakafi mai faɗi da yawa, ta yadda za a magance matsalar juriyar ƙwayoyin cuta.

An fuskanci wannan matsala mai amfani, ƙungiyar masu binciken kimiyya ta Fuji sun tashi don haɓaka na'urar gano ƙwayoyin cuta mai nau'i 15.

Wannan kit ɗin yana ɗaukar haɗin haɗin PCR kai tsaye da fasaha na PCR Multix, wanda zai iya gano Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Haemophilus influenzae da sauran 15 na gama gari na ƙananan sassan numfashi a cikin sputum a cikin kusan awa 1.Kwayoyin cututtuka na iya bambanta yadda ya kamata tsakanin kwayoyin halitta (kwayoyin cuta na al'ada) da kwayoyin cuta.Na yi imani za a sa ran ya zama ingantaccen kayan aiki don taimakawa likitocin a cikin ainihin amfani da magani.

A cikin fuskantar "super kwayoyin cuta", abokin gaba na jama'a na dukan mutane, dan Adam bai taba daukar shi da wasa ba.A fannin kimiyyar rayuwa, har yanzu akwai masu bincike da yawa kamar tawagar Song Xu da ke aiki tukuru don yin bincike da aiki tukuru a kan hanya don nemo hanyoyin magance “super bacteria”.

Anan, a madadin takwarorinsu na ilimin halitta da kuma wadanda suka amfana, Fortune Biotech na son nuna girmamawarta mafi girma ga dukkan masana kimiyya da suka sadaukar da kokarinsu da zufa kan hakan, tare da yin addu'a cewa ’yan Adam su sami nasara a kan “super bacteria” da wuri-wuri don samun lafiya da lafiya.kewaye.